Endocrine Abstracts

Aim: To evaluate sleep architecture of patients with Cushing’s disease (CD) and to explore whether agouti-related peptide (AgRP) leptin, and interleukin-6 (IL-6) play a permissive role in sleep alterations.Methods: We performed polysomnography on 26 patients with active CD and age 26 age- and sex-matched control subjects. Blood samples were obtained from all participants for the analyses of AgRP, leptin, and IL-6. The laboratory and sleep-related pa...

Aim: To investigate the volumetric changes in cortical and subcortical deep gray matter (GM) structures and cognitive alterations in patients with mild autonomous cortisol secretion (MACS). We also sought to assess whether the anticipated changes in brain volume and cognitive functions of the patients with MACS differ from the changes in patients with overt Cushing’s Syndrome (CS). Methods: In this cross-sectional study, volumes of the cortex, hippo...

Aim: To identify the causes and predictors of mortality in acromegaly patients diagnosed, treated, and followed in the Pituitary Center of Istanbul University-Cerrahpasa over the last three decades using machine learning (ML) models.Methods: The study sample consisted of 607 consecutive patients diagnosed with acromegaly at Cerrahpasa Faculty of Medicine during the period 1990 – 2023. The main inclusion criteria were age > 18 years and a clear-c...

Objective: To determine the frequency of polycystic ovary syndrome (PCOS) in women with prediabetes compared to control women.Methods: Digital screening and tele-interviews remotely excluded 3218 out of 3465 consecutive women applied for routine check-up. In-person assessments were performed on 247 women, excluding 49. Final analyses included 198 premenopausal women without endocrine disorders (other than prediabetes and PCOS) or conditions affecting gon...

Aim: To investigate the relationship between serum growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels, seminal plasma GH and IGF-1 levels, and sperm parameters in acromegalic patients.Methods: A cross-sectional study was conducted on 24 acromegaly patients (acromegaly group), 11 non-functioning adenoma (NFA) patients (NFA group), and 16 healthy men (control group). Seminal plasma GH and IGF-1 levels were measured. Semen parameters and se...

Aim: To determine the prevalence of impulse control disorder (ICD) in patients with Cushing’s disease (CD) treated with cabergoline (CBG) compared to CBG-naive patients with CD.Methods: We performed a cross-sectional study in patients with CD followed at 5 referral centers based in Istanbul. Eligible patients with CD were those with current CBG treatment for ≥ 3 months. Eligible controls were CBG-naive patients with CD that were matched for ag...

Introduction: APECED syndrome is characterized by the three most common components of the condition, i.e. mucocutaneous candidiasis, autoimmune hypoparathyroidism, and Addison’s disease. Presence of two of these components suffices for diagnosis.The case: A 33-year-old female patient presented to the endocrinology polyclinic for weakness, nausea, vomiting, dizziness, recurring vaginal itch, and discharge for 1 year, intermittent dysphagias and ameno...

Purpose: The authors review the clinical outcomes of patients with hypophysitis.Methods: Medical records of hypophysitis patients who were followed between 2007 and 2018 at Cerrahpasa Medical Faculty were evaluated retrospectively. Clinical, endocrinological, pathological and radiological findings and therapies were assessed.Results: Twenty patients (F/M:12/8) were identified with a mean age at diagnosis of 39.14±17.78 years. ...

Background/AimsGender affirming hormone therapy (GAHT) has been reported to have positive psychosocial effects on transgender people. In present study, we aimed to investigate longitudinally the short-term and long-term impacts on social adaptation, body image, features of alexithymia and aggression changes in transgender men after GAHT administration.MethodsThe single center, longitudinally follow-up study i...

Background/Aim: In literature, many previous studies adressed that Gender-affirmig Hormone Therapy (GAHT) improves the factors affecting social functioning such as self-esteem, mental well-being, behavioral health and quality of life. In this study, we aimed to quantitatively evaluate the effects of the GAHT on social functioning using a psychiatric scale in people with female-to-male (FtM) in Türkiye.Methods: The single center, cross-sectional stud...